The spectrum of COVID-19-associated dermatologic manifestations: An international registry of 716 patients from 31 countries

Freeman, Esther E.; McMahon, Devon E.; Lipoff, Jules B.; Rosenbach, Misha; Kovarik, Carrie; Desai, Seemal R.; Harp, Joanna; Takeshita, Junko; French, Lars E.; Lim, Henry W.; Thiers, Bruce H.; Hruza, George J. und Fox, Lindy P. (2020): The spectrum of COVID-19-associated dermatologic manifestations: An international registry of 716 patients from 31 countries. In: Journal of the American Academy of Dermatology, Bd. 83, Nr. 4: S. 1118-1129

Abstract

Background: Coronavirus disease 2019 (COVID-19) has associated cutaneous manifestations. Objective: To characterize the diversity of cutaneous manifestations of COVID-19 and facilitate understanding of the underlying pathophysiology. Methods: Case series from an international registry from the American Academy of Dermatology and International League of Dermatological Societies. Results: The registry collected 716 cases of new-onset dermatologic symptoms in patients with confirmed/suspected COVID-19. Of the 171 patients in the registry with laboratory-confirmed COVID-19, the most common morphologies were morbilliform (22%), pernio-like (18%), urticarial (16%), macular erythema (13%), vesicular (11%), papulosquamous (9.9%), and retiform purpura (6.4%). Pernio-like lesions were common in patients with mild disease, whereas retiform purpura presented exclusively in ill, hospitalized patients. Limitations: We cannot estimate incidence or prevalence. Confirmation bias is possible. Conclusions: This study highlights the array of cutaneous manifestations associated with COVID-19. Many morphologies were nonspecific, whereas others may provide insight into potential immune or inflammatory pathways in COVID-19 pathophysiology.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0190-9622
• Sprache: Englisch