Impact of severe left ventricular outflow tract calcification on device failure and short-term mortality in patients undergoing TAVI

Jochheim, David; Deseive, Simon; Gschwendtner, Sarah; Bischoff, Bernhard; Jochheim, Sarah; Hausleiter, Sebastian; Zadrozny, Magda; Baquet, Moritz; Tesche, Christian; Massberg, Steffen; Mehilli, Julinda und Hausleiter, Jörg (2020): Impact of severe left ventricular outflow tract calcification on device failure and short-term mortality in patients undergoing TAVI. In: Journal of Cardiovascular Computed Tomography, Bd. 14, Nr. 1: S. 36-41

Abstract

Background: To investigate the impact of left ventricular outflow tract (LVOT) calcification on the incidence of device failure and mortality in patients undergoing transcatheter aortic valve implantation (TAVI). Methods: Of 690 consecutive patients undergoing transfemoral TAVI in our center from January 2013 to December 2015, 600 presented with non-severe (NSCA(LVOT)) and 90 (13.0%) with severe (SCA(LVOT)) LVOT calcification. Primary outcome of interest was device failure defined as a composite of procedural death, prosthesis dislocation, annulus rupture or significant para-valvular leakage (PVL). Secondary outcome of interest was 30-day and one-year all-cause mortality. Results: Mean age of the population was 80.8 +/- 7.2 years, mean STS score was 5.7 +/- 4.6% and 50.6% of the patients were women. Patients with SCA(LVOT)( )more frequently experienced device failure (10.0% vs. 3.8%, p = 0.009) and were at higher risk of 30 day (10.0% vs. 2.8%, p < 0.001) all cause mortality as compared to those with NSCA(LVOT). Furthermore, patients with SCA(LVOT) were more frequently in need of post-dilation (15.6% vs. 8.5%, p = 0.032) and showed higher incidence of significant PVL (7.8% vs. 2.5%, p = 0.007). In multivariate analysis, SCA(LVOT) (hazard ratio 2.87;95% CI 1.20 to 6.34) and use of balloon-expandable prosthesis (hazard ratio 0.32;95% CI 0.15 to 0.73) were identified as independent predictors of device failure. Conclusion: Presence of severe LVOT calcification in patients undergoing transfemoral TAVI is associated with a higher risk of device failure and short-term mortality.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1934-5925
• Sprache: Englisch