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Karam, Nicole; Mehr, Michael; Taramasso, Maurizio; Besler, Christian; Ruf, Tobias; Connelly, Kim A.; Weber, Marcel; Yzeiraj, Ermela; Schiavi, Davide; Mangieri, Antonio; Vaskelyte, Laura; Alessandrini, Hannes; Deuschl, Florian; Brugger, Nicolas; Ahmad, Hasan; Ho, Edwin; Biasco, Luigi; Orban, Mathias; Deseive, Simon; Braun, Daniel; Gavazzoni, Mara; Rommel, Karl-Philipp; Pozzoli, Alberto; Frerker, Christian; Naebauer, Michael; Massberg, Steffen; Pedrazzini, Giovanni; Tang, Gilbert H. L.; Windecker, Stephan; Schaefer, Ulrich; Kuck, Karl-Heinz; Sievert, Horst; Denti, Paolo; Latib, Azeem; Schofer, Joachim; Nickenig, Georg; Fam, Neil; Bardeleben, Stephan von; Lurz, Philipp; Maisano, Francesco and Hausleiter, Jörg (2020): Value of Echocardiographic Right Ventricular and Pulmonary Pressure Assessment in Predicting Transcatheter Tricuspid Repair Outcome. In: Jacc-Cardiovascular Interventions, Vol. 13, No. 10: pp. 1251-1261

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OBJECTIVES The aim of this study was to assess the value of echocardiographic right ventricular (RV) and systolic pulmonary artery pressure (sPAP) assessment in predicting transcatheter tricuspid edge-to-edge valve repair (TTVR) outcome. Background: RV dysfunction and pulmonary hypertension are associated with poor prognosis and are systematically sought during tricuspid regurgitation evaluation. The value of echocardiographic assessment in predicting TTVR outcome is unknown. METHODS Data were taken from the TriValve (Transcatheter Tricuspid Valve Therapies) registry, which includes patients undergoing TTVR at 14 European and North American centers. The primary outcome was 1-year survival free from hospitalization for heart failure, and secondary outcomes were 1-year survival and absence of hospital admission for heart failure at 1 year. RESULTS Overall, 249 patients underwent TTVR between June 2015 and 2018 (mean tricuspid annular plane systolic excursion [TAPSE] 15.8 15.3 mm, mean sPAP 43.6 16.0 mm Hg). Tricuspid regurgitation grade $3thorn was found in 96.8% of patients at baseline and 29.4% at final follow-up;95.6% were in New York Heart Association functional class III or IV initially, compared with 34.3% at follow-up (p < 0.05). Final New York Heart Association functional class did not differ among TAPSE and sPAP quartiles, even when both low TAPSE and high sPAP were present. Rates of 1-year survival and survival free from hospitalization for heart failure were 83.9% and 78.7%, respectively, without significant differences according to baseline echocardiographic RV characteristics (TAPSE, fractional area change, and end-diastolic area) and sPAP (p > 0.05 for all). CONCLUSIONS TTVR provides clinical improvement, with 1-year survival free from hospital readmission >75% in patients with severe tricuspid regurgitation. Conventional echocardiographic parameters used to assess RV function and sPAP did not predict clinical outcome after TTVR.

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