Ribonucleoparticle-independent transport of proteins into mammalian microsomes

Zimmermann, Richard; Zimmermann, M.; Wiech, Hans; Schlenstedt, Gabriel; Müller, Günter; Morel, F.; Klappa, Peter; Jung, Christian und Cobet, Werner W. E. (Dezember 1990): Ribonucleoparticle-independent transport of proteins into mammalian microsomes. In: Journal of Bioenergetics and Biomembranes, Bd. 22, Nr. 6: S. 711-723

Abstract

There are at least two different mechanisms for the transport of secretory proteins into the mammalian endoplasmic reticulum. Both mechanisms depend on the presence of a signal peptide on the respective precursor protein and involve a signal peptide receptor on the cis-side and signal peptidase on the trans-side of the membrane. Furthermore, both mechanisms involve a membrane component with a cytoplasmically exposed sulfhydryl. The decisive feature of the precursor protein with respect to which of the two mechanisms is used is the chain length of the polypeptide. The critical size seems to be around 70 amino acid residues (including the signal peptide). The one mechanism is used by precursor proteins larger than about 70 amino acid residues and involves two cytosolic ribonucleoparticles and their receptors on the microsomal surface. The other one is used by small precursor proteins and relies on the mature part within the precursor molecule and a cytosolic ATPase.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Biologie > Department Biologie I
• Themengebiete: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
• ISSN: 1573-6881