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Kalhoff, Hermann; Mesch, Christina M.; Stimming, Madlen; Israel, Andreas; Spitzer, Christoph; Beganovic, Latifa; Perez, Rocio Estella; Koletzko, Berthold; Warschburger, Petra; Kersting, Mathilde; Libuda, Lars (2020): Effects of LC-PUFA supply via complementary food on infant development-a food based intervention (RCT) embedded in a total diet concept. In: European Journal of Clinical Nutrition, Vol. 74, No. 5: pp. 682-690
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Background: With the introduction of complementary food, long-chain PUFA (LC-PUFA) supply usually decreases during the second 6 months of life. However, the need for LC-PUFA is still high for infant's rapid development. The aim of this randomized, controlled intervention trial was to examine the effects of an increased n-3 (LC-)PUFA supply using alternative complementary foods on infants' visual and cognitive development. Methods Mother-child dyads of term infants were recruited in maternity hospitals and randomly assigned to one of three study groups, which all were fed according to the German dietary schedule for infant nutrition. Intervention group IG-R (n = 54) received jars of complementary food with rapeseed oil, IG-F (n = 48) jars with oily fish twice a week and the control group (CG, n = 58) the same jars as IG-R with corn oil instead of rapeseed oil during the intervention period (5th-10th month of age). The outcome measures were latencies of FVEP, Bayley's mental developmental index (MDI), and psychomotor developmental index (PDI). Results At 10 months of age, there were no significant differences in latencies of FVEP, Bayley's MDI, or in PDI index between the intervention and control groups. Conclusions: Fish and rapeseed oil used as (LC-)PUFA sources provided with complementary feeding embedded in a structured infant diet did not affect visual or cognitive development of term infants.