Trends in aeroallergen sensitization in Germany - An analysis of 2919 serological data sets of a university ENT department

Gellrich, Donata; Eder, Katharina; Englhard, Anna Sophie und Groeger, Moritz (2020): Trends in aeroallergen sensitization in Germany - An analysis of 2919 serological data sets of a university ENT department. In: Acta Oto-Laryngologica, Bd. 140, Nr. 5: S. 406-412

Abstract

Background: Recently, population-based birth-cohort studies provided an insight into the allergic march during childhood. Aims: Our study aimed to investigate sensitization pattern until advanced age. Patients and methods: Demographic, clinical and serological characteristics of 2919 patients with positive allergen-specific IgE between 1999 and 2019 were analyzed. We performed subgroup analysis of various age-groups and different years of birth to distinguish between age-dependent changes and birth-cohort-effects. Results: Since 1999, the proportion of sensitized children has significantly increased. The prevalence of sIgE towards most allergens reached its peak in adolescence or young adulthood. Only to mites, the highest rate of sensitization was found in childhood. With further aging, the prevalence of sIgE significantly decreased in most sensitizations. Only to Fagales, the highest rate of sensitization was observed among patients >65 years. The year-of-birth analysis proved the above-mentioned changes to be age-dependent. Further, it revealed various sensitization trends from older to younger generations.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0001-6489
• Sprache: Englisch