Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19

König, Lars M.; Boehmer, Daniel F. R.; Metzger, Philipp; Schnurr, Max; Endres, Stefan und Rothenfusser, Simon (2020): Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19. In: Journal of Experimental Medicine, Bd. 217, Nr. 9, e20201342

Abstract

An exacerbated and unbalanced immune response may account for the severity of COVID-19, the disease caused by the novel severe acute respiratory syndrome (SARS) coronavirus 2, SARS-CoV-2. In this Viewpoint, we summarize recent evidence for the role of neutrophils in the pathogenesis of COVID-19 and propose CXCR2 inhibition as a promising treatment option to block neutrophil recruitment and activation.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0022-1007
• Sprache: Englisch