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Carsin, Anne-Elie; Keidel, Dirk; Fuertes, Elaine; Imboden, Medea; Weyler, Joost; Nowak, Dennis; Heinrich, Joachim; Erquicia, Silvia Pascual; Martinez-Moratalla, Jesus; Huerta, Ismael; Sanchez, Jose-Luis; Schaffner, Emmanuel; Caviezel, Seraina; Beckmeyer-Borowko, Anna; Raherison, Chantal; Pin, Isabelle; Demoly, Pascal; Leynaert, Benedicte; Cerveri, Isa; Squillacioti, Giulia; Accordini, Simone; Gislason, Thorarinn; Svanes, Cecilie; Toren, Kjell; Forsberg, Bertill; Janson, Christer; Jogi, Rain; Emtner, Margareta; Real, Francisco Gomez; Jarvis, Debbie; Guerra, Stefano; Dharmage, Shyamali C.; Probst-Hensch, Nicole; Garcia-Aymerich, Judith (2020): Regular Physical Activity Levels and Incidence of Restrictive Spirometry Pattern: A Longitudinal Analysis of 2 Population-Based Cohorts. In: American Journal of Epidemiology, Vol. 189, No. 12: pp. 1521-1528
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We estimated the association between regular physical activity and the incidence of restrictive spirometry pattern. Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and physical activity were assessed in 2 population-based European cohorts (European Community Respiratory Health Survey: n = 2,757, aged 39-67 years;and Swiss Study on Air Pollution and Lung and Heart Diseases in Adults: n = 2,610, aged 36-82 years) first in 2000-2002 and again approximately 10 years later (2010-2013). Subjects with restrictive or obstructive spirometry pattern at baseline were excluded. We assessed the association of being active at baseline (defined as being physically active at least 2-3 times/week for >= 1 hour) with restrictive spirometry pattern at follow-up (defined as a postbronchodilation FEV1/FVC ratio of at least the lower limit of normal and FVC of <80% predicted) using modified Poisson regression, adjusting for relevant confounders. After 10 years of follow-up, 3.3% of participants had developed restrictive spirometry pattern. Being physically active was associated with a lower risk of developing this phenotype (relative risk = 0.76, 95% confidence interval: 0.59, 0.98). This association was stronger among those who were overweight and obese than among those of normal weight (P for interaction = 0.06). In 2 large European studies, adults practicing regular physical activity were at lower risk of developing restrictive spirometry pattern over 10 years.