Anti-dopamine D2 receptor antibodies in chronic tic disorders

Addabbo, Francesco; Baglioni, Valentina; Schrag, Anette; Schwarz, Markus J.; Dietrich, Andrea; Hoekstra, Pieter J.; Martino, Davide und Buttiglione, Maura (2020): Anti-dopamine D2 receptor antibodies in chronic tic disorders. In: Developmental Medicine and Child Neurology, Bd. 62, Nr. 10: S. 1205-1212

Abstract

Aim: To investigate the association between circulating anti-dopamine D2 receptor (D2R) autoantibodies and the exacerbation of tics in children with chronic tic disorders (CTDs). Method One hundred and thirty-seven children with CTDs (108 males, 29 females;mean age [SD] 10y 0mo [2y 7mo], range 4-16y) were recruited over 18 months. Patients were assessed at baseline, at tic exacerbation, and at 2 months after exacerbation. Serum anti-D2R antibodies were evaluated using a cell-based assay and blinded immunofluorescence microscopy scoring was performed by two raters. The association between visit type and presence of anti-D2R antibodies was measured with McNemar's test and repeated-measure logistic regression models, adjusting for potential demographic and clinical confounders. Results At exacerbation, 11 (8%) participants became anti-D2R-positive ('early peri-exacerbation seroconverters'), and nine (6.6%) became anti-D2R-positive at post-exacerbation ('late peri-exacerbation seroconverters'). The anti-D2R antibodies were significantly associated with exacerbations when compared to baseline (McNemar's odds ratio=11,p=0.003) and conditional logistic regression confirmed this association (Z=3.49,p<0.001) after adjustment for demographic and clinical data and use of psychotropic drugs. Interpretation There is a potential association between immune mechanisms and the severity course of tics in adolescents with CTDs.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0012-1622
• Sprache: Englisch