Abstract
Background: Data from clinical trials comparing Helicobacter pylori (H. pylori) management strategies in patients with dyspepsia are limited. Cost-effectiveness simulation models might help to identify the optimal strategy. Objective: To assess the cost-effectiveness of the H. pylori "Test and Treat" (T&T) strategy including the use of urea breath test (UBT) vs symptomatic treatment (ST) and vs upper gastrointestinal endoscopy (UGE) as a first procedure in patients with dyspepsia. Methods Three main strategies: "T&T" strategy including the use of UBT, "UGE" and "ST" have been compared using cost-effectiveness models developed in accordance with the Spanish medical practice. For the model simulations, a time horizon of 4 weeks was considered for the endpoint "Dyspepsia symptoms relief" and 10 years when using "Peptic ulcer avoided" and "Gastric cancer avoided" endpoints. Results For the endpoint "Dyspepsia symptoms relief", T&T strategy appears to be the most cost-effective (883euro/success) compared to UGE strategy and to ST strategy (respectively 1628euro and 990euro/success). For the endpoint "Probability of peptic ulcer", the T&T strategy appears to be the most cost-effective (421euro/peptic ulcer avoided/y) compared to UGE strategy and ST strategy (respectively 728euro and 632euro/peptic ulcer avoided/y). For the endpoint "Gastric cancer avoided", the T&T strategy appears to be the most cost-effective (524euro/gastric cancer avoided/y) compared to UGE strategy and "ST" strategy (respectively 716euro and 696euro/gastric cancer avoided/y). Conclusions: T&T strategy including the use of UBT is the most cost-effective medical approach for management of dyspepsia and for the prevention of ulcer and gastric cancer.
Dokumententyp: | Zeitschriftenartikel |
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Fakultät: | Medizin |
Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
ISSN: | 1083-4389 |
Sprache: | Englisch |
Dokumenten ID: | 86685 |
Datum der Veröffentlichung auf Open Access LMU: | 25. Jan. 2022, 09:20 |
Letzte Änderungen: | 25. Jan. 2022, 09:20 |