One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD)

Cunningham, Steve; Graham, Catriona; MacLean, Morag; Aurora, Paul; Ashworth, Michael; Barbato, Angelo; Calder, Alistair; Carlens, Julia; Clement, Annick; Hengst, Meike; Kammer, Birgit; Kiper, Nural; Krenke, Katarzyna; Kronfeld, Kai; Lange, Joanna; Ley-Zaporozhan, Julia; Nicholson, Andrew G.; Reu, Simone; Wesselak, Traudl; Wetzke, Martin; Bush, Andrew; Schwerk, Nicolaus and Griese, Matthias (2020): One-year outcomes in a multicentre cohort study of incident rare diffuse parenchymal lung disease in children (ChILD). In: Thorax, Vol. 75, No. 2: pp. 172-175

Abstract

We performed a prospective, observational, cohort study of children newly diagnosed with children's interstitial lung disease (ChILD), with structured follow-up at 4, 8, 12 weeks and 6 and 12 months. 127 children, median age 0.9 (IQR 0.3-7.9) years had dyspnoea (68%, 69/102), tachypnoea (75%, 77/103) and low oxygen saturation (SpO(2)) median 92% (IQR 88-96). Death (n=20, 16%) was the most common in those <6 months of age with SpO(2)<94% and developmental/surfactant disorders. We report for the first time that ChILD survivors improved multiple clinical parameters within 8-12 weeks of diagnosis. These data can inform family discussions and support clinical trial measurements.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0040-6376
• Alliance/National Licence: This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
• Language: English