Bragt, Job J. M. H. van; Adcock, Ian M.; Bel, Elisabeth H. D.; Braunstahl, Gert-Jan; Brinke, Anneke ten; Busby, John; Canonica, Giorgio W.; Cao, Hui; Chung, Kian Fan; Csoma, Zsuzsanna; Dahlen, Barbro; Davin, Elizabeth; Hansen, Susanne; Heffler, Enrico; Horvath, Ildiko; Korn, Stephanie; Kots, Maxim; Kuna, Piotr; Kwon, Namhee; Louis, Renaud; Plaza, Vicente; Porsbjerg, Celeste; Ramos-Barbon, David; Richards, Levi B.; Skrgat, Sabina; Sont, Jacob K.; Vijverberg, Susanne J. H.; Weersink, Els J. M.; Yasinska, Valentyna; Wagers, Scott S.; Djukanovic, Ratko; Maitland-van der Zee, Anke H.; Abenhardt, B.; Adcock, I. M.; Adler, J.; Alfonso, R.; Ali, R.; Alkameh, S.; Almonacid Sanchez, C.; Alvares, L.; Anderson, G.; Assing, K.; Ayre, S.; Becker, J.; Bel, E. H. D.; Bergmann, K.; Bieksiene, K.; Bjerring, N.; Blasi, F.; Bloemen, P.; Blum, H.; Boeing, S.; Bonavia, M.; Bossios, A.; Bourdin, A.; Braunstahl, G-J; Brons, A.; Brusselle, G.; Buis, J.; Busby, J.; Caiaffa, M.; Calabrese, C.; Camiciottoli, G.; Canonica, G. W.; Cao, H.; Caruso, C.; Castilla Martinez, M.; Centanni, S.; Chung, K. F.; Cisneros Serrano, C.; Corsico, A.; Cosmi, L.; Costantino, M.; Costello, R.; Crimi, N.; Csoma, Z.; Dahlen, S.; Dahlen, B.; D'Amato, M.; Davies, D.; Davin, E.; Garcia-Cosio Piqueras, F. de Borja; Decarlo, G.; Deimling, A.; Del Giacco, S.; Diaz Campos, R.; Djandji, M.; Djukanovic, R.; Doberer, D.; Dupont, L.; Dyett, K.; Edelbaher, N.; Edelmann, M.; Ehmann, R.; Ekberg-Jansson, A.; Farsi, A.; Favero, E.; Feimer, J.; Fletcher, M.; Foschino, B.; Frankemolle, B.; Gaga, M.; Gappa, M.; Garcia de Pedro, J.; Garcia Rivero, J.; Gasplmayr, M.; Gebhardt, R.; Geldmacher, H.; Geltner, C.; Gerstlauer, M.; Gibson, T.; Giuseppe, G.; Gogoll, C.; Grimm-Sachs, V.; Grisle, I.; Gruen, B.; Gruenewaldt, A.; Guarnieri, G.; Gullon Blanco, J.; Hamelmann, E.; Hamerlijnck, D.; Hammers-Reinhard, A.; Hanon, S.; Hansen, S.; Harzheim, D.; Heaney, L.; Heffler, E.; Hellmich, S.; Herden, M.; Hering, T.; Herth, F.; Hilberg, O.; Horvath, I.; Howarth, P.; Hubatsch, M.; Humbert, M.; Husemann, K.; Idzko, M.; Jackson, D.; Jandl, M.; Jaumont, X.; Joos, G.; Joest, M.; Juech, M.; Kabesch, M.; Kaiser-Labusch, P.; Kardos, P.; Kaessner, F.; Keeley, T.; Kerr, W.; Kirschner, J.; Klimek, L.; Koca, M.; Koczulla, R.; Koerner-Rettberg, C.; Kopac, P.; Korn, S.; Kots, M.; Kronsbein, J.; Kuna, P.; Lipinska, I. Kuprys; Kwon, N.; Langer, M.; Langeveld, B.; Lantz, A.; Lazarinis, N.; Lazic, Z.; Lehtimaki, L.; Leuppi, J.; Lombardi, C.; Lommatzsch, M.; Lopez-Vina, A.; Louis, R.; Luca, R.; Ludviksdottir, D.; Luettecke-Hecht, C.; Macchia, L.; Magni, T.; Maitland-van der Zee, A. H.; Martinez Rivera, C.; Mastoridis, P.; Mazza, F.; Menzella, F.; Menzies-Gow, A.; Michils, A.; Mihaltan, F.; Milanese, M.; Milger-Kneidinger, K.; Molinska, J.; Montagna, I.; Montuschi, P.; Muelleneisen, N.; Munoz Esquerre, M.; Nanzer-Kelly, A.; Nenasheva, N.; Neurohr, C.; Nucera, E.; Otker, J.; Oud, K.; Paggiaro, P.; Parente, R.; Parkinson, J.; Passalacqua, G.; Patberg, N.; Patella, V; Patino, O.; Paulsson, T.; Peche, R.; Pelaia, G.; Peress, E.; Perez de Llano, L.; Pfeffer, P.; Pfister, P.; Pilette, C.; Pinedo Sierra, C.; Pini, L.; Plaza, V.; Porsbjerg, C.; Powitz, F.; Ramos-Barbon, D.; Ranger, T.; Rasmussen, L.; Rasmussen, K.; Rezelj, M.; Ricciardi, L.; Ricciardolo, F.; Richards, L. B.; Ridolo, E.; Rijssenbeek-Nouwens, L.; Rolla, G.; Romero Ribate, D.; Rüdiger, S.; Safioti, G.; Sandstrom, T.; Santus, P.; Sauer, R.; Schauerte, G.; Schipmann, R.; Schleich, F.; Schmid, J.; Schmidt, F.; Schmidt, O.; Schmitz, M.; Schrag, T.; Schroeer, S.; Schultz, K.; Schulz, C.; Scichilone, N.; Sedlak, V.; Selb, J.; Senna, G.; Sergejeva, S.; Serrano Pariente, J.; Sichau, M.; Simona, D.; Singer, A.; Skowasch, D.; Skrgat, S.; Smeenk, F.; Smith, S.; Solidoro, P.; Sont, J. K.; Spadaro, G.; Spanevello, A.; Stefansdottir, M.; Steinmetz, K.; Steiss, J.; Stephan, M.; Stieglitz, S.; Suhling, H.; Taube, C.; Brinke, A. ten; Yavuz, S. Tolga; Tudoric, N.; Ulrik, C.; Bragt, J. J. M. H. van; Ven, M. van de; Elshout, F. van den; Dyke, M. van; Nederveen-Bendien, S. van; Veen, I. van; Vandenplas, O.; Velthove, K.; Vianello, A.; Vijverberg, S. J. H.; Vogelberg, C.; Wagers, S. S.; Wallen-Nielsen, E.; Weersink, E. J.; Wisskirchen, T.; Yacoub, M.; Yancey, S.; Yasinska, V.; Zappa, M.; Zielen, S.; Zimmermann, C. und Zimmermann, R.
(2020):
Characteristics and treatment regimens across ERS SHARP severe asthma registries.
In: European Respiratory Journal, Bd. 55, Nr. 1, 1901163
Volltext auf 'Open Access LMU' nicht verfügbar.
Abstract
Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This is the first study in the European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Research Collaboration and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals. This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases. Analysis of data from 3236 patients showed many differences in characteristics and lifestyle factors. Current smokers ranged from 0% (Poland and Sweden) to 9.5% (Belgium), mean body mass index ranged from 26.2 (Italy) to 30.6 kg.m(-2) (the UK) and the largest difference in mean pre-bronchodilator forced expiratory volume in 1 s % predicted was 20.9% (the Netherlands versus Hungary). Before starting biologicals patients were treated differently between countries: mean inhaled corticosteroid dose ranged from 700 to 1335 mu g.day(-1) between those from Slovenia versus Poland when starting anti-interleukin (IL)5 antibody and from 772 to 1344 mu g.day(-1) in those starting anti-IgE (Slovenia versus Spain). Maintenance oral corticosteroid use ranged from 21.0% (Belgium) to 63.0% (Sweden) and from 9.1% (Denmark) to 56.1% (the UK) in patients starting anti-IL-5 and anti-IgE, respectively. The severe asthmatic population in Europe is heterogeneous and differs in both clinical characteristics and treatment, often appearing not to comply with the current European Respiratory Society/American Thoracic Society guidelines definition of severe asthma. Treatment regimens before starting biologicals were different from inclusion criteria in clinical trials and varied between countries.
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