IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction

Joustra, Sjoerd D.; Roelfsema, Ferdinand; Trotsenburg, A. S. Paul van; Schneider, Harald J.; Kosilek, Robert P.; Kroon, Herman M.; Logan, John G.; Butterfield, Natalie C.; Zhou, Xiang; Toufaily, Chirine; Bak, Beata; Turgeon, Marc-Olivier; Brule, Emilie; Steyn, Frederik J.; Gurnell, Mark; Koulouri, Olympia; Le Tissier, Paul; Fontanaud, Pierre; Bassett, J. H. Duncan; Williams, Graham R.; Oostdijk, Wilma; Wit, Jan M.; Pereira, Alberto M.; Biermasz, Nienke R.; Bernard, Daniel J. und Schoenmakers, Nadia (2020): IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction. In: Journal of Clinical Endocrinology & Metabolism, Bd. 105, Nr. 3, E70-E84

Abstract

Context: The X-linked immunoglobulin superfamily, member 1 (IGSF1), gene is highly expressed in the hypothalamus and in pituitary cells of the POU1F1 lineage. Human loss-of-function mutations in IGSF1 cause central hypothyroidism, hypoprolactinemia, and macroorchidism. Additionally, most affected adults exhibit higher than average IGF-1 levels and anecdotal reports describe acromegaloid features in older subjects. However, somatotrope function has not yet been formally evaluated in this condition. Objective: We aimed to evaluate the role of IGSF1 in human and murine somatotrope function. Patients, Design, and Setting: We evaluated 21 adult males harboring hemizygous IGSF1 loss-of-function mutations for features of GH excess, in an academic clinical setting. Main Outcome Measures: We compared biochemical and tissue markers of GH excess in patients and controls, including 24-hour GH profile studies in 7 patients. Parallel studies were undertaken in male Igsf1-deficient mice and wild-type littermates. Results: IGSF1-deficient adult male patients demonstrated acromegaloid facial features with increased head circumference as well as increased finger soft-tissue thickness. Median serum IGF-1 concentrations were elevated, and 24-hour GH profile studies confirmed 2- to 3-fold increased median basal, pulsatile, and total GH secretion. Male Igsf1-deficient mice also demonstrated features of GH excess with increased lean mass, organ size, and skeletal dimensions and elevated mean circulating IGF-1 and pituitary GH levels. Conclusions: We demonstrate somatotrope neurosecretory hyperfunction in IGSF1-deficient humans and mice. These observations define a hitherto uncharacterized role for IGSF1 in somatotropes and indicate that patients with IGSF1 mutations should be evaluated for long-term consequences of increased GH exposure.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0021-972X
• Sprache: Englisch