S3-Leitlinie: Sepsis 2018 Prävention, Diagnose, Therapie und Nachsorge – Zusammenfassung starker Empfehlungen

Brunkhorst, F. M.; Weigand, M. A.; Pletz, M.; Gastmeier, P.; Lemmen, S. W.; Meier-Hellmann, A.; Ragaller, M.; Weyland, A.; Marx, G.; Bucher, M.; Gerlach, H.; Salzberger, B.; Grabein, B.; Welte, T.; Werdan, K.; Kluge, S.; Bone, H. G.; Putensen, C.; Rossaint, R.; Quintel, M.; Spies, C.; Weiss, B.; John, S.; Oppert, M.; Jörres, A.; Brenner, T.; Elke, G.; Gründling, M.; Mayer, K.; Weimann, A.; Felbinger, T. W.; Axer, I. I.; Heller, H. and Gagelmann, N. (2020): S3-Leitlinie: Sepsis 2018 Prävention, Diagnose, Therapie und Nachsorge – Zusammenfassung starker Empfehlungen. In: Anästhesiologie & Intensivmedizin, Vol. 61: pp. 178-188

Abstract

Sepsis is an acute life-threatening organ dysfunction resulting from an inadequate host response to an infection. The diagnosis of sepsis-associated organ dysfunction should be based on a change of >= 2 points using the Sequential Organ Failure Assessment (SOFA) score. An intravenous crystalloid solution should be administered within the first 3 hours to achieve a haemodynamic stabilisation of the patient. A 0.9% NaCl solution should NOT be used. A schematic minimum infusion amount and a general target value for the mean arterial blood pressure are not recommended. Intravenous anti-infectives should be administered as soon as possible if possible within 1 hour after confirmed diagnosis. The application of an empirical broad-spectrum antibiotic or multiple antibiotics is recommended in order to account for all significant bacteria. Measurements of the procalcitonin value should be done to shorten the duration of antimicrobial therapy.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0170-5334
• Language: German