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Brunkhorst, F. M., Weigand, M. A., Pletz, M., Gastmeier, P., Lemmen, S. W., Meier-Hellmann, A., Ragaller, M., Weyland, A., Marx, G., Bucher, M., Gerlach, H., Salzberger, B., Grabein, B., Welte, T., Werdan, K., Kluge, S., Bone, H. G., Putensen, C., Rossaint, R., Quintel, M., Spies, C., Weiss, B., John, S., Oppert, M., Jörres, A., Brenner, T., Elke, G., Gründling, M., Mayer, K., Weimann, A., Felbinger, T. W., Axer, I. I., Heller, H. and Gagelmann, N. (2020): S3-Leitlinie: Sepsis 2018 Prävention, Diagnose, Therapie und Nachsorge – Zusammenfassung starker Empfehlungen. In: Anästhesiologie & Intensivmedizin, Vol. 61: pp. 178-188

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Sepsis is an acute life-threatening organ dysfunction resulting from an inadequate host response to an infection. The diagnosis of sepsis-associated organ dysfunction should be based on a change of >= 2 points using the Sequential Organ Failure Assessment (SOFA) score. An intravenous crystalloid solution should be administered within the first 3 hours to achieve a haemodynamic stabilisation of the patient. A 0.9% NaCl solution should NOT be used. A schematic minimum infusion amount and a general target value for the mean arterial blood pressure are not recommended. Intravenous anti-infectives should be administered as soon as possible if possible within 1 hour after confirmed diagnosis. The application of an empirical broad-spectrum antibiotic or multiple antibiotics is recommended in order to account for all significant bacteria. Measurements of the procalcitonin value should be done to shorten the duration of antimicrobial therapy.

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