Exploratory analysis of the platelet-to-lymphocyte ratio prognostic value in the adjuvant renal cell cancer setting

Patel, Anup; Ravaud, Alain; Motzer, Robert J.; Pantuck, Allan J.; Staehler, Michael; Escudier, Bernard; Martini, Jean-Francois; Lechuga, Mariajose; Lin, Xun und George, Daniel J. (2020): Exploratory analysis of the platelet-to-lymphocyte ratio prognostic value in the adjuvant renal cell cancer setting. In: Future Oncology, Bd. 17, Nr. 4: S. 403-409

Abstract

Aim:To examine the prognostic value of the platelet-to-lymphocyte ratio (PLR) in the adjuvant renal cell carcinoma setting.Materials & methods:Patients received adjuvant sunitinib (50 mg/day;4 weeks on/2 weeks off) or placebo. The primary end point was disease-free survival (DFS).Results:In 609 patients, DFS was similar for baseline PLR <140 versus >= 140 overall (median: 6.4 vs 5.9 years;hazard ratio: 0.9;95% CI: 0.7-1.2). A >= 25% decrease in PLR at week 4 overall was associated with longer DFS versus no change (hazard ratio: 0.8;95% CI: 0.6-1.0).Conclusion:Baseline PLR was not prognostic for DFS with adjuvant sunitinib treatment in patients with renal cell carcinoma. Clinical Trials Registration:()

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1479-6694
• Sprache: Englisch