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Schmidt, Konrad; Gensichen, Jochen; Fleischmann-Struzek, Carolin; Bahr, Viola; Pausch, Christine; Sakr, Yasser; Reinhart, Konrad; Vollmar, Horst Christian; Thiel, Paul; Scherag, Andre; Gantner, Julia; Brunkhorst, Frank M. (2020): Long-Term Survival Following Sepsis. In: Deutsches Ärzteblatt International, Vol. 117, No. 46: pp. 775-782
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Abstract

Background: There have not yet been any prospective registry studies in Germany with active investigation of the long-term survival of patients with sepsis. Methods: The Jena Sepsis Registry (JSR) included all patients with a diagnosis of sepsis in the four intensive care units of Jena University Hospital from January 2011 to December 2015. Long-term survival 6-48 months after diagnosis was documented by asking the treating general practitioners. The survival times were studied with Kaplan-Meier estimators. Cox regressions were calculated to show associations between possible predictors and survival time. Results: 1975 patients with sepsis or septic shock were included. The mean time of observation was 730 days. For 96.4% of the queries to the general practitioners, information on long-term survival was available. Mortality in the intensive care unit was 34% (95% confidence interval [32;37]), and in-hospital mortality was 45% [42;47]. The overall mortality six months after diagnosis was 59% [57;62], the overall mortality 48 months after diagnosis was 74% [72;78]. Predictors of shorter survival were age, nosocomial origin of sepsis, diabetes, cerebrovascular disease, duration of stay in the intensive care unit, and renal replacement therapy. Conclusion: The nearly 75% mortality four years after diagnosis indicates that changes are needed both in the acute treatment of patients with sepsis and in their multi-sector long-term care. The applicability of these findings may be limited by their having been obtained in a single center.