Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor beta 1 Are Inversely Associated with Survival in Primary Breast Cancer

Shao, Wanting; Kuhn, Christina; Mayr, Doris; Ditsch, Nina; Kailuweit, Magdalena; Wolf, Verena; Harbeck, Nadia; Mahner, Sven; Jeschke, Udo; Cavailles, Vincent und Sixou, Sophie (2020): Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor beta 1 Are Inversely Associated with Survival in Primary Breast Cancer. In: International Journal of Molecular Sciences, Bd. 21, Nr. 1, 330

Abstract

The aim of this study was to investigate the expression of thyroid hormone receptor beta 1 (THR beta 1) by immunohistochemistry in breast cancer (BC) tissues and to correlate the results with clinico-biological parameters. In a well-characterized cohort of 274 primary BC patients, THR beta 1 was widely expressed with a predominant nuclear location, although cytoplasmic staining was also frequently observed. Both nuclear and cytoplasmic THR beta 1 were correlated with high-risk BC markers such as human epidermal growth factor receptor 2 (HER2), Ki67 (also known as MKI67), prominin-1 (CD133), and N-cadherin. Overall survival analysis demonstrated that cytoplasmic THR beta 1 was correlated with favourable survival (p = 0.015), whereas nuclear THR beta 1 had a statistically significant correlation with poor outcome (p = 0.038). Interestingly, in our cohort, nuclear and cytoplasmic THR beta 1 appeared to be independent markers either for poor (p = 0.0004) or for good (p = 0.048) prognosis, respectively. Altogether, these data indicate that the subcellular expression of THR beta 1 may play an important role in oncogenesis. Moreover, the expression of nuclear THR beta 1 is a negative outcome marker, which may help to identify high-risk BC subgroups.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch