The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease

Bosmans, Laura A.; Bosch, Lena; Kusters, Pascal J. H.; Lutgens, Esther und Seijkens, Tom T. P. (2020): The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease. In: Journal of Cardiovascular Translational Research, Bd. 14, Nr. 1: S. 13-22

Abstract

Chronic inflammation drives the development of atherosclerosis. Despite optimal treatment of classical cardiovascular risk factors, a substantial portion of the population has elevated inflammatory biomarkers and develops atherosclerosis-related complications, indicating that a residual inflammatory risk drives atherosclerotic cardiovascular disease in these patients. Additional anti-inflammatory therapeutic strategies are therefore required. The co-stimulatory molecule CD40 and its ligand CD40L (CD154) have a central role in the regulation of the inflammatory response during the development of atherosclerosis by modulating the interaction between immune cells and between immune cells and non-immune cells. In this review, we discuss the role of the CD40-CD40L dyad in atherosclerosis, and we discuss recent studies on the therapeutic potential of novel CD40-CD40L targeting strategies in cardiovascular medicine.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1937-5387
• Sprache: Englisch