Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

D'Alessandro, Elisa; Becker, Christian; Bergmeier, Wolfgang; Bode, Christoph; Bourne, Joshua H.; Brown, Helena; Buller, Harry R.; Cate-Hoek, Arina J. ten; Cate, Vincent ten; Cauteren, Yvonne J. M. van; Cheung, Yam F. H.; Cleuren, Audrey; Coenen, Danielle; Crijns, Harry J. G. M.; de Simone, Ilaria; Dolleman, Sophie C.; Klein, Christine Espinola; Fernandez, Delia I.; Granneman, Lianne; Hof, Arnoud van t; Henke, Peter; Henskens, Yvonne M. C.; Huang, Jingnan; Jennings, Lisa K.; Jooss, Natalie; Karel, Mieke; Kerkhof, Danique van den; Klok, Frederik A.; Kremers, Bram; Laemmle, Bernhard; Leader, Avi; Lundstrom, Annika; Mackman, Nigel; Mannucci, Pier M.; Maqsood, Zahra; Meijden, Paola E. J. van der; Moorsel, Marc van; Moran, Luis A.; Morser, John; Mourik, Manouk van; Navarro, Stefano; Neagoe, Raluca A. I.; Olie, Renske H.; Paridon, Pauline van; Posma, Jens; Provenzale, Isabella; Reitsma, Pieter H.; Scaf, Billy; Schurgers, Leon; Seelig, Jaap; Siegbahn, Agneta; Siegerink, Bob; Soehnlein, Oliver; Soriano, Eva Maria; Sowa, Marcin A.; Spronk, Henri M. H.; Storey, Robert F.; Tantiwong, Chukiat; Veninga, Alicia; Wang, Xueqing; Watson, Steve P.; Weitz, Jeff; Zeerleder, Sacha S. und Cate, Hugo ten (2020): Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis. In: Thrombosis and Haemostasis, Bd. 120, Nr. 4: S. 538-564

Abstract

Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier;(2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps;(3) procoagulant mechanisms;(4) arterial vascular changes in atherogenesis;attenuating atherosclerosis and ischemia/reperfusion injury;(5) management of patients with arterial vascular disease;and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0340-6245
• Sprache: Englisch