The immunomodulatory role of Regnase family RNA-binding proteins

Fischer, Maximilian; Weinberger, Tobias und Schulz, Christian (2020): The immunomodulatory role of Regnase family RNA-binding proteins. In: Rna Biology, Bd. 17, Nr. 12: S. 1721-1726

Abstract

RNA-binding proteins regulate RNA fate and govern post-transcriptional gene regulation. A new family of RNA-binding proteins is represented by regulatory RNases (Regnase, also known as Zc3h12 or MCPIP), which have emerged as important players in immune homoeostasis. Four members, Regnase1-4, have been identified to date. Here we summarize recent findings on the role of Regnase in the regulation of RNA biology and its consequences for cell functions and inflammatory processes.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1547-6286
• Sprache: Englisch