What Do We Currently Know about the Pathophysiology of Alcoholic Pancreatitis: A Brief Review

Zorniak, Michal; Sirtl, Simon; Mayerle, Julia und Beyer, Georg (2020): What Do We Currently Know about the Pathophysiology of Alcoholic Pancreatitis: A Brief Review. In: Visceral Medicine, Bd. 36, Nr. 3: S. 182-190

Abstract

Background:Alcoholic pancreatitis is a serious medical concern worldwide and remains to be one of the common causes of pancreatic disease.Summary:While alcohol consumption causes direct damage to pancreatic tissue, only a small percentage of active drinkers will develop pancreatitis. An explanation of this phenomenon is probably that alcohol increases pancreatic vulnerability to damage;however, the simultaneous presence of additional risk factors and pancreatic costressors is required to increase the risk of pancreatitis and its complications caused by alcohol misuse. Recently, a number of important genetic as well as environmental factors influencing the risk of alcoholic pancreatitis have been described.Key Messages:In brief, this review reports established factors for the development of alcoholic pancreatitis and summarizes recent progress made in basic and clinical research.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 2297-4725
• Sprache: Englisch