Organophosphorus Compounds and MAPK Signaling Pathways

Farkhondeh, Tahereh; Mehrpour, Omid; Buhrmann, Constanze; Pourbagher-Shahri, Ali Mohammad; Shakibaei, Mehdi und Samarghandian, Saeed (2020): Organophosphorus Compounds and MAPK Signaling Pathways. In: International Journal of Molecular Sciences, Bd. 21, Nr. 12, 4258

Abstract

The molecular signaling pathways that lead to cell survival/death after exposure to organophosphate compounds (OPCs) are not yet fully understood. Mitogen-activated protein kinases (MAPKs) including the extracellular signal-regulated protein kinase (ERK), the c-Jun NH2-terminal kinase (JNK), and the p38-MAPK play the leading roles in the transmission of extracellular signals into the cell nucleus, leading to cell differentiation, cell growth, and apoptosis. Moreover, exposure to OPCs induces ERK, JNK, and p38-MAPK activation, which leads to oxidative stress and apoptosis in various tissues. However, the activation of MAPK signaling pathways may differ depending on the type of OPCs and the type of cell exposed. Finally, different cell responses can be induced by different types of MAPK signaling pathways after exposure to OPCs.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch