Abstract
TIM-3 has been considered as a target in cancer immunotherapy. In T cells, inhibitory as well as activating functions have been ascribed to this molecule. Its role may therefore depend on the state of T cells and on the presence of interaction partners capable to perform functional pairing. Carcinoembryonic antigen-related cell adhesion molecule (CEACAM1) has been proposed to bind TIM-3 and to regulate its function. Using a T cell reporter platform we confirmed CEACAM1-mediated inhibition, but CEACAM1 did not functionally engage TIM-3. TIM-3 and CEACAM1 coexpression was limited to a small subset of activated T cells. Moreover, results obtained in extensive binding studies were in support of an interaction between TIM-3 and CEACAM1. Cytoplasmic sequences were derived from TIM-3-induced inhibitory signaling in our human T cell reporter system. Our results indicate that TIM-3 functions are independent of CEACAM1 and that this receptor has the capability to promote inhibitory signaling pathways in human T cells.
Dokumententyp: | Zeitschriftenartikel |
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Fakultät: | Tiermedizin |
Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
ISSN: | 0014-2980 |
Sprache: | Englisch |
Dokumenten ID: | 88151 |
Datum der Veröffentlichung auf Open Access LMU: | 25. Jan. 2022, 09:26 |
Letzte Änderungen: | 25. Jan. 2022, 09:26 |