Antibody response to feline herpesvirus-1 vaccination in healthy adult cats

Bergmann, Michele; Speck, Stephanie; Rieger, Anna; Truyen, Uwe und Hartmann, Katrin (2020): Antibody response to feline herpesvirus-1 vaccination in healthy adult cats. In: Journal of Feline Medicine and Surgery, Bd. 22, Nr. 4: S. 329-338

Abstract

Objectives: Vaccination against feline herpesvirus-1 (FHV-1) is recommended for all cats. However, it is unknown how adult healthy cats with different pre-vaccination antibodies respond to FHV-1 vaccination in the field. The aim of the study was to determine the prevalence of neutralising antibodies against FHV-1 in healthy adult cats and the response to FHV-1 vaccination within 28 days of vaccination. Methods One hundred and ten cats (> 1 year of age) that had not received a vaccination within the past 12 months were vaccinated with a combined FHV-1 vaccine. Antibodies against FHV-1 were determined before vaccination (day 0), on day 7 and day 28 by serum neutralisation test. Uni- and multivariate statistical analyses were used to determine factors associated with the presence of pre-vaccination antibodies and response to vaccination. Results: Pre-vaccination neutralising antibody titres (> 10) were present in 40.9% of cats (45/110;95% confidence interval [CI] 32.2-50.3);titres were generally low (range 10-640). Antibody response to vaccination (> four-fold titre increase) was observed in 8.3% (9/109;95% CI 4.2-15.1). Cats > 2 years of age were more likely to have pre-vaccination neutralising antibodies than cats aged between 1 and 2 years (odds ratio [OR] 24.619;P = 0.005). Cats from breeders were more likely to have pre-vaccination neutralising antibodies than privately owned cats (OR 7.070;P = 0.007). Domestic shorthair cats were more likely to have an at least four-fold titre increase vs purebred cats (OR 11.22;P = 0.027). Conclusions and relevance: Many cats have no detectable neutralising antibodies against FHV-1 despite previous vaccinations and fail to develop a > four-fold titre increase after vaccination. This is likely because older cats and cats with a higher FHV-1 exposure risk are more likely to get infected with FHV-1 and thus to have FHV-1 neutralizing antibodies. Purebred cats more often fail to develop a > four-fold titre increase after vaccination.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Tiermedizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1098-612X
• Sprache: Englisch