Antibody Response to Canine Adenovirus-2 Virus Vaccination in Healthy Adult Dogs

Bergmann, Michele; Freisl, Monika; Zablotski, Yury; Speck, Stephanie; Truyen, Uwe und Hartmann, Katrin (2020): Antibody Response to Canine Adenovirus-2 Virus Vaccination in Healthy Adult Dogs. In: Viruses-Basel, Bd. 12, Nr. 10, 1198

Abstract

Background: Re-vaccination against canine adenovirus (CAV) is performed in <= 3-year-intervals but its necessity is unknown. The study determined anti-CAV antibodies within 28 days of re-vaccination and factors associated with the absence of antibodies and vaccination response. Methods: Ninety-seven healthy adult dogs (last vaccination >= 12 months) were re-vaccinated with a modified live CAV-2 vaccine. Anti-CAV antibodies were measured before vaccination (day 0), and after re-vaccination (day 7, 28) by virus neutralization. A >= 4-fold titer increase was defined as vaccination response. Fisher's exact test and multivariate regression analysis were performed to determine factors associated with the absence of antibodies and vaccination response. Results: Totally, 87% of dogs (90/97;95% CI: 85.61-96.70) had anti-CAV antibodies (>= 10) before re-vaccination. Vaccination response was observed in 6% of dogs (6/97;95% CI: 2.60-13.11). Time since last vaccination (>3-5 years, OR = 9.375, p = 0.020;>5 years, OR = 25.000, p = 0.006) was associated with a lack of antibodies. Dogs from urban areas were more likely to respond to vaccination (p = 0.037). Conclusion: Many dogs had anti-CAV pre-vaccination antibodies, even those with an incomplete vaccination series. Most dogs did not respond to re-vaccination. Based on this study, dogs should be re-vaccinated every 3 years or antibodies should be determined.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Tiermedizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch