Continuous Flow Sodiation of Substituted Acrylonitriles, Alkenyl Sulfides and Acrylates

Harenberg, Johannes H.; Weidmann, Niels; Karaghiosoff, Konstantin und Knochel, Paul (2020): Continuous Flow Sodiation of Substituted Acrylonitriles, Alkenyl Sulfides and Acrylates. In: Angewandte Chemie-International Edition, Bd. 60, Nr. 2: S. 731-735

Abstract

The sodiation of substituted acrylonitriles and alkenyl sulfides in a continuous flow set-up using NaDA (sodium diisopropylamide) in EtNMe2 or NaTMP (sodium 2,2,6,6-tetramethylpiperidide).TMEDA in n-hexane provides sodiated acrylonitriles and alkenyl sulfides, which are subsequently trapped in batch with various electrophiles such as aldehydes, ketones, disulfides and allylic bromides affording functionalized acrylonitriles and alkenyl sulfides. This flow-procedure was successfully extended to other acrylates by using Barbier-type conditions.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1433-7851
• Sprache: Englisch