Bis-cyclometalated Iridium Complexes Containing Modified Phenanthroline Ligands and Evaluation of their Cytotoxic Activities

Graf, Marion; Boettcher, Hans-Christian; Sünkel, Karlheinz; Thavalingam, Sugina; Metzler-Nolte, Nils und Czerwieniec, Rafal (2020): Bis-cyclometalated Iridium Complexes Containing Modified Phenanthroline Ligands and Evaluation of their Cytotoxic Activities. In: Zeitschrift für Anorganische und Allgemeine Chemie, Bd. 647, Nr. 4: S. 306-311

Abstract

The synthesis and characterization of new bis-cyclometalated complex salts [Ir(ptpy)(2)(L-phen)]PF6 with L-phen = 2,9-dimethyl-4,7-bis(pentyloxy)-1,10-phenanthroline (1) and L-phen = 2,9-dimethyl-4,7-bis(2-ethoxyethoxyl)-1,10-phenanthroline (2) are described. Compounds 1 and 2 were obtained by the reaction of the corresponding phenanthroline ligands with [{Ir(mu-Cl)(ptpy)(2)}(2)] in a refluxing CH2Cl2/MeOH mixture. The molecular structure of compound 2 was confirmed by single-crystal X-ray structure determination. Complex 2 was crystallized from dichloromethane/methanol/iso-hexane in the monoclinic space group P2(1)/c. The biological activity of both new compounds was examined, and they exhibit significant cytotoxicity against human cancer cell lines with the IC50 values around 2 mu M, significantly better than the established anticancer drug cisplatin under identical conditions.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0044-2313
• Sprache: Englisch