Pyridinyl Amide Ion Pairs as Lewis Base Organocatalysts

Helberg, Julian; Ampssler, Torsten und Zipse, Hendrik (2020): Pyridinyl Amide Ion Pairs as Lewis Base Organocatalysts. In: Journal of Organic Chemistry, Bd. 85, Nr. 8: S. 5390-5402

Abstract

Pyridinyl amide ion pairs carrying various electron-withdrawing substituents were synthesized with selected ammonium or phosphonium counterions. Compared to neutral pyridine-based organocatalysts, these new ion pair Lewis bases display superior catalytic reactivity in the reaction of isocyanates with alcohols and the aza-Morita-Baylis-Hillman reaction of hindered electrophiles. The high catalytic activity of ion pair catalysts appears to be due to their high Lewis basicities toward neutral electrophiles as quantified through quantum chemically calculated affinity data.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0022-3263
• Sprache: Englisch