Cobalt-Catalyzed Csp(3)-Csp(3) Cross-Coupling of Functionalized Alkylzinc Reagents with Alkyl Iodides

Lutter, Ferdinand H.; Grokenberger, Lucie; Benz, Maximilian und Knochel, Paul (2020): Cobalt-Catalyzed Csp(3)-Csp(3) Cross-Coupling of Functionalized Alkylzinc Reagents with Alkyl Iodides. In: Organic Letters, Bd. 22, Nr. 8: S. 3028-3032

Abstract

A mild cobalt-catalyzed Negishi-type cross-coupling of various functionalized dialkylzinc reagents with primary and secondary alkyl iodides in acetonitrile is reported using a combination of 20% CoCl2 and chelating nitrogen ligands. The method allows the construction of molecules with alkyl chains bearing sensitive functional groups at room temperature.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1523-7060
• Sprache: Englisch