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Cox, Sarah J.; Camargo, Diana C. Rodriguez; Lee, Young-Ho; Dubini, Romeo C. A.; Rovo, Petra; Ivanova, Magdalena I.; Padmini, Vediappen; Reif, Bernd and Ramamoorthy, Ayyalusamy (2020): Small molecule induced toxic human-IAPP species characterized by NMR. In: Chemical Communications, Vol. 56, No. 86: pp. 13129-13132

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In this study, the effect of CurDAc, a water-soluble curcumin derivative, on the formation and stability of amyloid fibers is revealed. CurDAc interaction with amyloid is structurally selective, which is reflected in a strong interference with hIAPP aggregation while showing weaker interactions with human-calcitonin and amyloid-beta (1-40) in comparison. Remarkably, CurDAc also exhibited potent fiber disaggregation for hIAPP generating a toxic oligomeric species.

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