Abstract
A halogen-lithium exchange in the presence of MgCl2 center dot LiCl on a broad range of heterocyclic scaffolds using a commercial flow set-up withnBuLi as exchange reagent is reported. The resulting diheteroarylmagnesium species were subsequently trapped with various electrophiles, such as ketones, aldehydes, allylic bromides, or disulfides affording functionalized heterocycles. A scale-up was performed by simply increasing the run-time without further optimizations.
Item Type: | Journal article |
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Faculties: | Chemistry and Pharmacy > Department of Chemistry |
Subjects: | 500 Science > 540 Chemistry |
ISSN: | 0039-7881 |
Language: | English |
Item ID: | 90021 |
Date Deposited: | 25. Jan 2022, 09:33 |
Last Modified: | 25. Jan 2022, 09:33 |