Iron-Catalyzed Cross-Coupling of Bis-(aryl)manganese Nucleophiles with Alkenyl Halides: Optimization and Mechanistic Investigations

Rousseau, Lidie; Desaintjean, Alexandre; Knochel, Paul und Lefevre, Guillaume (2020): Iron-Catalyzed Cross-Coupling of Bis-(aryl)manganese Nucleophiles with Alkenyl Halides: Optimization and Mechanistic Investigations. In: Molecules, Bd. 25, Nr. 3, 723

Abstract

Various substituted bis-(aryl)manganese species were prepared from aryl bromides by one-pot insertion of magnesium turnings in the presence of LiCl and in situ trans-metalation with MnCl2 in THF at -5 degrees C within 2 h. These bis-(aryl)manganese reagents undergo smooth iron-catalyzed cross-couplings using 10 mol% Fe(acac)(3) with various functionalized alkenyl iodides and bromides in 1 h at 25 degrees C. The aryl-alkenyl cross-coupling reaction mechanism was thoroughly investigated through paramagnetic H-1-NMR, which identified the key role of tris-coordinated ate-iron(II) species in the catalytic process.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• Sprache: Englisch