Stereoselective Preparation and Reactions of Chiral Secondary Alkyllithiums

Skotnitzki, Juri; Kremsmair, Alexander und Knochel, Paul (2020): Stereoselective Preparation and Reactions of Chiral Secondary Alkyllithiums. In: Synthesis-Stuttgart, Bd. 52, Nr. 2: S. 189-196

Abstract

The preparation of chiral non-stabilized open-chain alkyl-lithium reagents prepared from the corresponding chiral secondary alkyl iodides and their subsequent transmetalation to the corresponding secondary alkylcopper or alkylzinc derivatives is reviewed. These new organometallic reagents allow the stereoselective preparation of a broad range of chiral molecules. 1 Introduction 2 Stereoselective Preparation of Secondary Alkyllithiums 3 Preparation of Stereodefined Secondary Alkylcopper Reagents 4 Preparation of Stereodefined Secondary Alkylzinc Derivatives and Their Stereoselective Cross-Coupling with Alkenyl and Aryl Halides 5 Conclusion

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0039-7881
• Sprache: Englisch