Stereoselective Access to Azetidine-Based alpha-Amino Acids and Applications to Small Peptide Synthesis

Reiners, Felix; Joseph, Emanuel; Nissl, Benedikt und Didier, Dorian (2020): Stereoselective Access to Azetidine-Based alpha-Amino Acids and Applications to Small Peptide Synthesis. In: Organic Letters, Bd. 22, Nr. 21: S. 8533-8537

Abstract

Non-natural azetidine-based amino acids (Aze) present interesting features in protein engineering. A simple organometallic route toward unsaturated carboxylic acid precursors is presented. Subsequent metal-catalyzed asymmetric reduction allowed for the synthesis of a new library of 2-azetidinylcarboxylic acids, which were finally employed in the formation of small peptide chains.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1523-7060
• Sprache: Englisch