Stereoselective Access to Azetidine-Based alpha-Amino Acids and Applications to Small Peptide Synthesis

Reiners, Felix; Joseph, Emanuel; Nissl, Benedikt and Didier, Dorian (2020): Stereoselective Access to Azetidine-Based alpha-Amino Acids and Applications to Small Peptide Synthesis. In: Organic Letters, Vol. 22, No. 21: pp. 8533-8537

Abstract

Non-natural azetidine-based amino acids (Aze) present interesting features in protein engineering. A simple organometallic route toward unsaturated carboxylic acid precursors is presented. Subsequent metal-catalyzed asymmetric reduction allowed for the synthesis of a new library of 2-azetidinylcarboxylic acids, which were finally employed in the formation of small peptide chains.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1523-7060
• Language: English