Tuning the toxixity of phosphonium based biocides using the bioisosteric CH2F moiety

Reichel, Marco; Unger, Cornelia; Dubovnik, Sviatlana; Roidl, Andreas; Kornath, Andreas and Karaghiosoff, Konstantin (2020): Tuning the toxixity of phosphonium based biocides using the bioisosteric CH2F moiety. In: Phosphorus Sulfur and Silicon and the Related Elements, Vol. 195, No. 11: pp. 947-948

Abstract

Tertiary alkyl, aryl or amino phosphines PR3(R = Me,nBu, C2H4CN, NEt2) and the bis(phosphine) POP were allowed to react with fluoroiodomethane to produce fluoromethyl phosphonium salts. New crystal structures of forming fluoromethyl phosphonium salts [R3PCH2F]I with R = Me, C2H2CN and NEt(2)were obtained and gave additional information of the nearly unknown P-CH2F moiety. The toxicity of the water soluble salt [Me3PCH2F]I was investigated compared to the biocide THPS.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1042-6507
• Language: English