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Gasperotti, Ana; Brameyer, Sophie; Fabiani, Florian; Jung, Kirsten (2020): Phenotypic heterogeneity of microbial populations under nutrient limitation. In: Current Opinion in Biotechnology, Vol. 62: pp. 160-167
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Abstract

Phenotypic heterogeneity is a phenomenon in which genetically identical individuals have different characteristics. This behavior can also be found in bacteria, even if they grow as monospecies in well-mixed environments such as bioreactors. Here it is discussed how phenotypic heterogeneity is generated by internal factors and how it is promoted under nutrient-limited growth conditions. A better understanding of the molecular levels that control phenotypic heterogeneity could improve biotechnological production processes.