ORCID: https://orcid.org/0000-0003-0046-983X
(2020):
Inside-out: from endosomes to extracellular vesicles in fungal RNA transport.
In: Fungal Biology Reviews, Vol. 34, No. 2: pp. 89-99
Abstract
Membrane-coupled RNA transport is an emerging theme in fungal biology. This review focuses on the RNA cargo and mechanistic details of transport via two inter-related sets of organelles: endosomes and extracellular vesicles for intra- and intercellular RNA transfer. Simultaneous transport and translation of messenger RNAs (mRNAs) on the surface of shuttling endosomes is a conserved process pertinent to highly polarised eukaryotic cells, such as hyphae or neurons. Here we detail the endosomal mRNA transport machinery components and mRNA targets of the core RNA-binding protein Rrm4. Extracellular vesicles (EVs) are newly garnering interest as mediators of intercellular communication, especially between pathogenic fungi and their hosts. Landmark studies in plant-fungus interactions indicate EVs as a means of delivering various cargos, most notably small RNAs (sRNAs), for cross-kingdom RNA interference. Recent advances and implications of the nascent field of fungal EVs are discussed and potential links between endosomal and EV-mediated RNA transport are proposed. (C) 2020 British Mycological Society. Published by Elsevier Ltd. All rights reserved.
Item Type: | Journal article |
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Faculties: | Biology > Department Biology I |
Subjects: | 500 Science > 570 Life sciences; biology |
ISSN: | 1749-4613 |
Language: | English |
Item ID: | 90208 |
Date Deposited: | 25. Jan 2022, 09:34 |
Last Modified: | 17. Jan 2023, 15:22 |