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Uhl, Edgar; Wolff, Friederike; Mangal, Sriyash; Dube, Henry and Zanin, Esther (2020): Light-Controlled Cell-Cycle Arrest and Apoptosis. In: Angewandte Chemie-International Edition, Vol. 60, No. 3: pp. 1187-1196

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The versatile proteasome inhibitor MG132 is inactivated with a photolabile protection group at its reactive aldehyde function, as described by Esther Zanin et al. in their Research Article (DOI: 10.1002/anie.202008267). Upon blue light irradiation MG132 activity is restored and cancer cells arrest either during metaphase of the cell cycle or die by apoptosis.

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