Light-Controlled Cell-Cycle Arrest and Apoptosis

Uhl, Edgar; Wolff, Friederike; Mangal, Sriyash; Dube, Henry und Zanin, Esther (2020): Light-Controlled Cell-Cycle Arrest and Apoptosis. In: Angewandte Chemie-International Edition, Bd. 60, Nr. 3: S. 1187-1196

Abstract

The versatile proteasome inhibitor MG132 is inactivated with a photolabile protection group at its reactive aldehyde function, as described by Esther Zanin et al. in their Research Article (DOI: 10.1002/anie.202008267). Upon blue light irradiation MG132 activity is restored and cancer cells arrest either during metaphase of the cell cycle or die by apoptosis.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Biologie > Department Biologie II
• Themengebiete: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
• ISSN: 1433-7851
• Sprache: Englisch