Light-Controlled Cell-Cycle Arrest and Apoptosis

Uhl, Edgar; Wolff, Friederike; Mangal, Sriyash; Dube, Henry und Zanin, Esther (2020): Light-Controlled Cell-Cycle Arrest and Apoptosis. In: Angewandte Chemie-International Edition, Vol. 60, No. 3: pp. 1187-1196

Abstract

The versatile proteasome inhibitor MG132 is inactivated with a photolabile protection group at its reactive aldehyde function, as described by Esther Zanin et al. in their Research Article (DOI: 10.1002/anie.202008267). Upon blue light irradiation MG132 activity is restored and cancer cells arrest either during metaphase of the cell cycle or die by apoptosis.

• Item Type: Journal article
• Faculties: Biology > Department Biology II
• Subjects: 500 Science > 570 Life sciences; biology
• ISSN: 1433-7851
• Language: English