| Kielkowski, Pavel; Buchsbaum, Isabel Y.; Becker, Tobias; Bach, Kathrin; Cappello, Silvia; Sieber, Stephan A. (2020): A Pronucleotide Probe for Live-Cell Imaging of Protein AMPylation. In: Chembiochem, Vol. 21, No. 9: pp. 1285-1287 |
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Abstract
Conjugation of proteins to AMP (AMPylation) is a prevalent post-translational modification (PTM) in human cells, involved in the regulation of unfolded protein response and neural development. Here we present a tailored pronucleotide probe suitable for in situ imaging and chemical proteomics profiling of AMPylated proteins. Using straightforward strain-promoted azide-alkyne click chemistry, the probe provides stable fluorescence labelling in living cells.
| Item Type: | Journal article |
|---|---|
| Research Centers: | Graduate School of Systemic Neurosciences (GSN) |
| Subjects: | 500 Science > 500 Science |
| ISSN: | 1439-4227 |
| Language: | English |
| ID Code: | 90648 |
| Deposited On: | 25. Jan 2022 09:36 |
| Last Modified: | 25. Jan 2022 09:36 |
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