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Gutierrez-Herrera, Maria; Eger, Simone; Keller, Ingo; Hermsdoerfer, Joachim and Saevarsson, Styrmir (2020): Neuroanatomical and behavioural factors associated with the effectiveness of two weekly sessions of prism adaptation in the treatment of unilateral neglect. In: Neuropsychological Rehabilitation, Vol. 30, No. 2: pp. 187-206

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Among the different interventions to alleviate the symptoms of unilateral neglect, prism adaptation (PA) appears especially promising. To elucidate the contribution of some neuroanatomical and behavioural factors to PA's effectiveness, we conducted a study combining neuropsychological and lesion mapping methods on a group of 19 neglect patients who underwent two sessions of PA during one week and assessed their improvement relative to the baseline until the following week (7-8 days later). Correlation analyses revealed a significant positive relationship between the magnitude of the proprioceptive after-effect and the improvement at the follow-up session in two perceptual tasks requiring motor responses. Conversely, no correlation was found between the proprioceptive after-effect and the improvement in a perceptual task with no motor involvement. This finding suggests that patients' potential to show a prism-related improvement in motor-related tasks might be indicated by the strength of their proprioceptive response (proprioceptive after-effect). As for the neuroanatomical basis of this relationship, subtraction analyses suggested that patients' improvement in perceptual tasks with high motor involvement might be facilitated by the integrity of temporo-parietal areas and the damage of frontal and subcortical areas.

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