Risk projections in time

Kellerer, Albrecht M. (1993): Risk projections in time. In: Chinese journal of radiological medicine and protection, Bd. 13, Nr. 6: S. 398-403

Abstract

The nominal risk coefficients for radiation induced cancer are largely based on the follow-up of the mortality from solid cancers among the atomic bomb survivors. For those who have been exposed as adults, the observations are essentially complete, and the risk estimates are, therefore, firmly based on observations. Those who have been exposed as children, have still not reached the age of high cancer incidence. Their observation is, therefore, still incomplete, and the risk estimates are correspondingly uncertain. The modelling of risk has predominantly been based on the postulate, that the relative risk (i.e. the actual cancer rate divided by the age specific normal rate) depend on dose and on age at exposure, and that it does not decline with time since exposure. The high relative risks observed at young ages lead, therefore, with this type of model, to high estimates of life time attributable risk. The ICRP recommendations contain these high risk estimates for young ages at exposure; the high sensitivity of children and juveniles has, indeed, become one of the basic tenets of radiation protection. It is here shown that these conclusions are still hypothetical, because they are merely a matter of the choice of the model. An alternative model assumes a dependence of the excess relative risk on age attained, rather than age at exposure. This model fits the data equally well, and predicts no increased risk for young ages at exposure. A decision between the two models is not possible at present, it will have to await the continued follow- up of those who survived the atomic bombs as children. The ICRP has been criticised for postulating a dose reduction factor (DDREF) in their nominal risk coefficients. If they abandoned this factor, and used the age attained model, rather than their present model, their numerical risk coefficients would remain unchanged.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0254-5098
• Sprache: Englisch