Scherthan, Harry; Cremer, Thomas; Arnason, U.; Weier, Heinz-Ulrich; Lima-de-Faria, A.; Fönicke, L. (1994): Comparative chromosome painting discloses homologous Segments in distantly related mammals. In: Nature Genetics, Vol. 6: S. 342-347




Comparative chromosome painting, termed ZOO-FISH, using DNA libraries from flow sorted human chromosomes 1,16,17 and X, and mouse chromosome 11 discloses the presence of syntenic groups in distantly related mammalian Orders ranging from primates (Homo sapiens), rodents (Mus musculus), even-toed ungulates (Muntiacus muntjak vaginalis and Muntiacus reevesi) and whales (Balaenoptera physalus). These mammalian Orders have evolved separately for 55-80 million years (Myr). We conclude that ZOO-FISH can be used to generate comparative chromosome maps of a large number of mammalian species.