Increased self-reported sensitivity to environmental stimuli and its effects on perception of air quality and well-being

Reichherzer, Anna; Wargocki, Pawel; Mayer, Florian; Norrefeldt, Victor und Herbig, Britta (April 2022): Increased self-reported sensitivity to environmental stimuli and its effects on perception of air quality and well-being.

Abstract

Background: In previous studies, negative associations were found between increased environmental sensitivity and general well-being as well as positive perception of air quality. However, only a few studies with partly inconsistent results examined this relation under exposure. They tried to determine whether people with increased environmental sensitivity react to real environmental conditions with changes in current well-being and perception of air quality. Methods: Pooled data from two single-blinded randomized controlled trials with different exposure levels were analyzed. Participants were exposed to different levels of volatile organic compounds (VOC) and carbon dioxide (CO2) in the front part of a former in-service wide-body airplane inserted in a low-pressure chamber. Three exposure groups were created depending on the VOC/CO2 levels: low, medium and high. Subjects repeatedly answered questions about their current mental well-being and about perception of air quality and odor intensity. Based on self-reported data the participants were classified into groups with low and higher environmental sensitivity. Data were evaluated using a 2 (environmental sensitivity) x 3 (exposure) ANCOVA with repeated measures. Results: 503 individuals (221 females) participated (mean age: 42.8±14.5 years). Thereof, 166 individuals were assigned to the group with higher environmental sensitivity; they reported poorer psychological well-being regarding vitality (F(1,466) = 16.42, p < .001***, partial η² = .034) and vigilance (F(1,467) = 7.82, p = .005**, partial η² = .016) and rated the pleasantness of air quality (F(1,476) = 7.55, p = .006**, partial η² = .016) and air movement (F(1,474) = 5.11, p = .024*, partial η² = .011) worse than people in the low sensitivity group. Exposure levels showed no effects. No systematic differences between men and women were found. Increased environmental sensitivity shared common variance with negative affectivity, another person-related variable. Its explanatory power was higher for evaluations of the environment whereas no differences between the concepts in explaining current psychological well-being were found. Conclusions: Even a slightly elevated level of environmental sensitivity led to worse ratings of the environment with no clear relation to the real environment. Consequently, environmental sensitivity should be considered as a confounding factor in environmental exposure studies. The independency from real exposure levels is in line with the results from previous studies showing that the differences in environmental ratings are probably also driven by psychological factors.

• Dokumententyp: Paper
• EU Funded Grant Agreement Number: 820872
• EU-Projekte: Horizon 2020 > Sonstige > Joint Technology Initiative > Joint Technology Initiative - Clean Sky 2
• Keywords: Environmental sensitivity, Exposure study, Randomized controlled trial, Aircraft cabin air
• Fakultät: Medizin > Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch

Literaturliste

Alobid, I., Nogué, S., Izquierdo-Dominguez, A., Centellas, S., Bernal-Sprekelsen, M., Mullol, J., 2014. Multiple chemical sensitivity worsens quality of life and cognitive and sensorial features of sense of smell. European Archives of Oto-Rhino-Laryngology: Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 271(12), 3203–3208. https://doi.org/10.1007/s00405-014-3015-5.

Andersson, L., Claeson, A.-S., Nyberg, L., Stenberg, B., Nordin, S., 2014. Brain responses to olfactory and trigeminal exposure in idiopathic environmental illness (IEI) attributed to smells – An fMRI study. Journal of Psychosomatic Research, 77(5), 401–408. https://doi.org/10.1016/j.jpsychores.2014.09.014.

Andersson, L., Johansson, A., Millqvist, E., Nordin, S., Bende, M., 2008. Prevalence and risk factors for chemical sensitivity and sensory hyperreactivity in teenagers. International Journal of Hygiene and Environmental Health, 211(5–6), 690–697. https://doi.org/10.1016/j.ijheh.2008.02.002.

Azuma, K., Uchiyama, I., Kunugita, N., 2019. Factors affecting self-reported chemical intolerance: A five-year follow-up study in Japan. Journal of Psychosomatic Research, 118, 1–8. https://doi.org/10.1016/j.jpsychores.2019.01.001.

Azuma, K., Uchiyama, I., Takano, H., Tanigawa, M., Azuma, M., Bamba, I., Yoshikawa, T., 2013. Changes in cerebral blood flow during olfactory stimulation in patients with multiple chemical sensitivity: a multi-channel near-infrared spectroscopic study. PloS One, 8(11), e80567. https://doi.org/10.1371/journal.pone.0080567.

Bailer, J., Rist, F., Witthöft, M., Paul, C., Bayerl, C., 2004. Symptom patterns, and perceptual and cognitive styles in subjects with multiple chemical sensitivity (MCS). Journal of Environmental Psychology, 24(4), 517–525. https://doi.org/10.1016/j.jenvp.2004.08.002.

Bailer, J., Witthöft, M., Bayerl, C., Rist, F., 2007. Syndrome stability and psychological predictors of symptom severity in idiopathic environmental intolerance and somatoform disorders. Psychological Medicine, 37(2), 271–281. https://doi.org/10.1017/S0033291706009354.

Bartha, L., Baumzweiger, W., Buscher, D.S., Callender, T., Dahl, K.A., et al., 1999. Multiple Chemical Sensitivity: A 1999 consensus. Archives of Environmental Health. An International Journal, 54(3), 147–149. https://doi.org/10.1080/00039899909602251.

Bauer A, Schwarz E, Mai C., 2008. Multiple Chemical Sensitivity (MCS): Ein Update. Umwelt Medizin Gesellschaft, 21(4), 9–15.

Berg, N. D., Rasmussen, H. B., Linneberg, A., Brasch-Andersen, C., Fenger, M., Dirksen, A., Vesterhauge, S., Werge, T., Elberling, J., 2010. Genetic susceptibility factors for multiple chemical sensitivity revisited. International Journal of Hygiene and Environmental Health, 213(2), 131–139. https://doi.org/10.1016/j.ijheh.2010.02.001.

Black, D.W., Okiishi, C., Schlosser, S., 2000. A nine-year follow-up of people diagnosed with multiple chemical sensitivities. Psychosomatics. 41(3), 253–261. https://doi.org/10.1176/appi.psy.41.3.253.

Bornschein, S., Hausteiner, C., Drzezga, A., Theml, T., Heldmann, B., Grimmer, T., Perneczky, R., Jahn, T., Schwaiger, M., Zilker, T., Förstl, H., 2007. Neuropsychological and positron emission tomography correlates in idiopathic environmental intolerances. Scandinavian Journal of Work, Environment & Health, 33(6), 447–453. https://doi.org/10.5271/sjweh.1164.

Bornschein, S., Hausteiner, C., Römmelt, H., Nowak, D., Förstl, H., Zilker, T., 2008. Double-blind placebo-controlled provocation study in patients with subjective Multiple Chemical Sensitivity (MCS) and matched control subjects. Clinical Toxicology, 46(5), 443–449. https://doi.org/10.1080/15563650701742438.

Brauer, C., Mikkelsen, S., 2010. The influence of individual and contextual psychosocial work factors on the perception of the indoor environment at work: a multilevel analysis. International Archives of Occupational and Environmental Health, 83(6), 639–651. https://doi.org/10.1007/s00420-010-0511-9.

Budie, B., Appel-Meulenbroek, R., Kemperman, A., Weijs-Perree, M., 2019. Employee satisfaction with the physical work environment: the importance of a need based approach. International Journal of Strategic Property Management. 23(1), 36–49. https://doi.org/10.3846/ijspm.2019.6372.

Chen, R., Fang, L., Liu, J., Herbig, B., Norrefeldt, V., Mayer, F., Fox, R. and Wargocki, P., 2021. Cabin air quality on non-smoking commercial flights: A review of published data on airborne pollutants. Indoor Air, 31(4), 926–957. https://doi.org/10.1111/ina.12831.

Cheung, T., Graham, L. T., Schiavon, S., 2022. Impacts of life satisfaction, job satisfaction and the Big Five personality traits on satisfaction with the indoor environment. Building and Environment, 212, 108783, https://doi.org/10.1016/j.buildenv.2022.108783.

Choi, J., Aziz, A., Loftness, V., 2010. Investigation on the impacts of different genders and ages on satisfaction with thermal environments. Office buildings, Building and Environment, 45, 1529–1535. https://doi.org/10.1016/j.buildenv.2010.01.004.

Christian, H., Lester, L., Trost, S. G., Schipperijn, J., Pereira, G., Franklin, P., Wheeler, A. J., 2021. Traffic exposure, air pollution and children’s physical activity at early childhood education and care. International Journal of Hygiene and Environmental Health, 240, 113885. https://doi.org/10.1016/j.ijheh.2021.113885.

Cohen, J., 1992. A power primer. Psychological Bulletin, 112(1), 155–159. https://doi.org/10.1037/0033-2909.112.1.155.

Cohen, P., Cohen, J., Aiken, L.S., West, S.G., 1999. The Problem of Units and the Circumstance for POMP. Multivariate Behavioral Research, 34(3), 315–346. https://doi.org/10.1207/S15327906MBR3403_2.

Cullen, M. R., 1987. The worker with multiple chemical sensitivities: an overview. Occupational medicine, 2(4), 655–661.

Driesen, L., Patton, R., John, M., 2020. The impact of multiple chemical sensitivity on people's social and occupational functioning; a systematic review of qualitative research studies. Journal of Psychosomatic Research, 132, 109964. https://doi.org/10.1016/j.jpsychores.2020.109964.

Ellert, U., Lampert, T., Ravens-Sieberer, U., 2005. Messung der gesundheitsbezogenen Lebensqualität mit dem SF-8. Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz, 48(12), 1330–1337.

Ellis, P.D., 2010. The essential guide to effect sizes: Statistical power, meta-analysis, and the interpretation of research results. Cambridge, New York: Cambridge University Press.

FAA (Federal Aviation Administration), 2019. Federal Aviation Regulations (FAR) Part 25 Airworthiness standards: Transport category airplanes, Washington, DC, USA.

Genius, S.J., 2010. Sensitivity-related illness: The escalating pandemic of allergy, food intolerance and chemical sensitivity. Science of The Total Environment, 408(24), 6047–6061. https://doi.org/10.1016/j.scitotenv.2010.08.047.

Georgellis, A., Lindelöf, B., Lundin, A., Arnetz, B., Hillert, L., 2003. Multiple chemical sensitivity in male painters; a controlled provocation study. International Journal of Hygiene and Environmental Health, 206(6), 531–538. https://doi.org/10.1078/1438-4639-00253.

Gößwald, A., Lange, M., Kamtsiuris, P., Kurth, B.M., 2012. DEGS: Studie zur Gesundheit Erwachsener in Deutschland. Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz, 55(6-7), 775–780.

Grün, G., Trimmel, M., Holm, A., 2012. Low humidity in the aircraft cabin environment and its impact on well-being – Results from a laboratory study. Building & Environment, 47, 23–31. https://doi.org/10.1016/j.buildenv.2011.05.004.

Hausteiner, C., Bornschein, S., Hansen, J., Zilker, T., Förstl, H., 2005. Self-reported chemical sensitivity in Germany: a population-based survey. International Journal of Hygiene and Environmental Health, 208(4), 271–278. https://doi.org/10.1016/j.ijheh.2005.03.006.

Hillert, L., Musabasic, V., Berglund, H., Ciumas, C., Savic, I., 2007. Odor processing in multiple chemical sensitivity. Human Brain Mapping, 28(3), 172–182. https://doi.org/10.1002/hbm.20266.

Hobi, V., 1985. Basler Befindlichkeitsskala [Basel Emotional State Scale]. Weinheim: Beltz Test Gesellschaft.

Johnson, D., Colman, I., 2017. The association between multiple chemical sensitivity and mental illness: Evidence from a nationally representative sample of Canadians. Journal of Psychosomatic Research, 99, 40–44. https://doi.org/10.1016/j.jpsychores.2017.06.002.

Karjalainen, S., 2007. Gender differences in thermal comfort and use of thermostats in everyday thermal environments. Building & Environment, 42(4), 1594–1603. https://doi.org/10.1016/j.buildenv.2006.01.009

Kiesswetter, E., Sietmann, B., Golka, K., Zupanic, M. Seeber, A., 1997. Discriminant validity of a new questionnaire for chemical and general environment sensitivity. Neurotoxicology, 18, 902–903.

Klepeis, N.E., Nelson, W.C., Ott, W.R., Robinson, J.P., Tsang, A.M., Switzer, P., Behar, J.V., Hern, S.C., Engelmann, W.H., 2001. The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants. Journal of Exposure Analysis and Environmental Epidemiology, 11(3), 231–252. https://doi.org/10.1038/sj.jea.7500165.

Lundberg, A., 1996. Psychiatric Aspects of Air Pollution. Otolaryngology–Head and Neck Surgery, 114(2), 227–231. https://doi.org/10.1016/S0194-59989670172-9.

McDowell, I., 2010. Measures of self-perceived well-being. Journal of Psychosomatic Research, 69(1), 69–79. https://doi.org/10.1016/j.jpsychores.2009.07.002.

Norrefeldt, V., Mayer, F., Herbig, B., Ströhlein, R., Wargocki, P., Lei, F., 2021. Effect of Increased Cabin Recirculation Airflow Fraction on Relative Humidity, CO2 and TVOC. Aerospace, 8(15). https://doi.org/10.3390/aerospace8010015.

Nordin S., 2020. Mechanisms underlying nontoxic indoor air health problems: A review. International Journal of Hygiene and Environmental Health, 226, 113489. https://doi.org/10.1016/j.ijheh.2020.113489.

Ojima, M., Tonori, H., Sato, T., Sakabe, K., Miyata, M., Ishikawa, S., Aizawa, Y., 2002. Odor perception in patients with multiple chemical sensitivity. The Tohoku Journal of Experimental Medicine, 198(3), 163–173. https://doi.org/10.1620/tjem.198.163.

Papo, D., Eberlein-König, B., Berresheim, H.-W., Huss-Marp, J., Grimm, V., Ring, J., Behrendt, H., Winneke, G., 2006. Chemosensory function and psychological profile in patients with multiple chemical sensitivity: Comparison with odor-sensitive and asymptomatic controls. Journal of Psychosomatic Research, 60(2), 199–209. https://doi.org/10.1016/j.jpsychores.2005.06.075.

Perera, E., 2010. Ideal Cabin Environment (ICE) Project: Overview. In Proceedings of the ICE International Aviation Conference, Munich, Germany. Platts-Mills, T.A., 2015. The allergy epidemics: 1870-2010. Journal of Allergy and Clinical Immunology. 136(1), 3–13. https://doi.org/10.1016/j.jaci.2015.03.048.

Robert-Koch-Institut, 2008. DEGS – Studie zur Gesundheit Erwachsener in Deutschland. Gesundheitsfragebogen 18 bis 64 Jahre (Stand: Marz 2009). Berlin: Robert-Koch-Institut.

Rossi, S., Pitidis, A., 2018. Multiple Chemical Sensitivity: Review of the state of the art in epidemiology, diagnosis, and future perspectives. Journal of Occupational and Environmental Medicine, 60(2), 138–146. https://doi.org/10.1097/JOM.0000000000001215.

Schneider, B. A., Avivi-Reich, M., Mozuraitis, M. 2015. A cautionary note on the use of the Analysis of Covariance (ANCOVA) in classification designs with and without within-subject factors. Frontiers in Psychology, 6, 474. https://doi.org/10.3389/fpsyg.2015.00474.

Siegel, S., Kreutzer, R., 1997. Pavlovian conditioning and multiple chemical sensitivity. Environmental Health Perspectives, 105 (2), 521–526. https://doi.org/10.1289/ehp.97105s2521.

Skovbjerg, S., Christensen, K. B., Ebstrup, J. F., Linneberg, A., Zachariae, R., Elberling, J., 2015. Negative affect is associated with development and persistence of chemical intolerance: A prospective population-based study. Journal of Psychosomatic Research, 78(5), 509–514. https://doi.org/10.1016/j.jpsychores.2015.02.005.

Steinemann, A., 2018. National prevalence and effects of Multiple Chemical Sensitivities. Journal of Occupational and Environmental Medicine, 60(3), e152–e156. https://doi.org/10.1097/JOM.0000000000001272.

Terr A. I., 1987. Multiple chemical sensitivities: immunologic critique of clinical ecology theories and practice. Occupational Medicine (Philadelphia, Pa.), 2(4), 683–694.

van Thriel, C., Kiesswetter, E., Schäper, M., Juran, S. A., Blaszkewicz, M., Kleinbeck, S., 2008. Odor annoyance of environmental chemicals: sensory and cognitive influences. Journal of Toxicology and Environmental Health. Part A, 71(11–12), 776–785. https://doi.org/10.1080/15287390801985596.

Veitch, J.A., Charles, K.E., Farley, K.M.J., Newsham, G.R., 2007. A model of satisfaction with open-plan office conditions: COPE field findings. Journal of Environmental Psychology, 27(3), 177–189. https://doi.org/10.1016/j.jenvp.2007.04.002.

Viljoen, M., Thomas Neé Negrao, B.L., 2021. Low-grade systemic inflammation and the workplace. Work (Reading, Mass.), 69(3), 903–915. https://doi.org/10.3233/WOR-213523.

Van den Bergh, O., Brown, R. J., Petersen, S., Witthoeft, M., 2017. Idiopathic Environmental Intolerance: A Comprehensive Model. Clinical Psychological Science, 5(3), 551-567. https://doi.org/10.1177/2167702617693327.

von Mutius, E., Vercelli, D., 2010. Farm living: effects on childhood asthma and allergy. Nature Reviews. Immunology, 10(12), 861–868. https://doi.org/10.1038/nri2871.

Ware, J.E., Kosinski, M., Dewey, J.E., Gandek, B., 2001. How to Score and Interpret Single-Item Health Status Measures: A manual for users of the SF-8 Health Survey. Lincoln, RI: Quality Metric Incorporated.

Wargocki, P., 2001. Measurements of the effects of air quality on sensory perception. Chemical Senses, 26(3), 345–348. https://doi.org/10.1093/chemse/26.3.345.

Watson, D., Clark, L., Tellegen, A., 1988. Development and validation of brief measures of positive and negative affect: The PANAS scales. Journal of Personality and Social Psychology, 54(6), 1063–1070. https://doi.org/10.1037/0022-3514.54.6.1063.

Witthöft, M., Gerlach, A. L., Bailer, J., 2006. Selective attention, memory bias, and symptom perception in idiopathic environmental intolerance and somatoform disorders. Journal of Abnormal Psychology, 115(3), 397–407. https://doi.org/10.1037/0021-843X.115.3.397.

Ziem, G., McTamney, J., 1997. Profile of patients with chemical injury and sensitivity. Environmental Health Perspectives, 105 (2), 417–436. https://doi.org/10.1289/ehp.97105s2417.