Binuclear Cu(II) complex based on N-acetylanthranilic acid induces significant cytotoxic effect on three cancer cell lines

Aly, Aref A. M.; Zidan, Amna S. A.; Ibrahim, Ahmed B. M.; Mosbah, Hanan K.; Mayer, Peter und Saber, Saber H. (2021): Binuclear Cu(II) complex based on N-acetylanthranilic acid induces significant cytotoxic effect on three cancer cell lines. In: Journal of Molecular Structure, Bd. 1249, 131634

Abstract

This paper presents the isolation of single crystals of an anionic Cu(II) complex (NH4)(NHEt3)[Cu-2(L)(4)Cl-2]{HL = N-acetylanthranilic acid and NEt3= triethylamine}. The analyses revealed the complex packing in the triclinic P-1 space group in addition to its dimeric structure and the octahedral geometry around the Cu(II)ions. In the complex, all the four carboxylate ligands are bridging the two Cu(II) centers and the charge on the anionic complex is compensated by an ammonium and protonated triethylamine ions. This Cu(II) complex is interestingly exerting highly significant cytotoxic effect on MDA-MB-231 breast cancer cells with IC(50)of 131.2 mu g/ml and moderate anti-proliferative activity against both PC-3 prostatic cancer and T-24 transitional cell carcinoma cells with IC50 of 200.7 and 300.3 mu g/ml, respectively. (C) 2021 Elsevier B.V. All rights reserved.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0022-2860
• Sprache: Englisch