Loss of direct adrenergic innervation after peripheral nerve injury causes lymph node expansion through IFN-gamma

Chen, Chien-Sin; Weber, Jasmin; Holtkamp, Stephan Jonas; Ince, Louise Madeleine; de Juan, Alba; Wang, Chen; Lutes, Lydia; Barnoud, Coline; Kizil, Burak; Hergenhan, Sophia Martina; Salvermoser, Johanna; Lasch, Manuel; Deindl, Elisabeth; Schraml, Barbara; Baumjohann, Dirk und Scheiermann, Christoph (2021): Loss of direct adrenergic innervation after peripheral nerve injury causes lymph node expansion through IFN-gamma. In: Journal of Experimental Medicine, Bd. 218, Nr. 8, e20202377

Abstract

Peripheral nerve injury can cause debilitating disease and immune cell-mediated destruction of the affected nerve. While the focus has been on the nerve-regenerative response, the effect of loss of innervation on lymph node function is unclear. Here, we show that the popliteal lymph node (popLN) receives direct neural input from the sciatic nerve and that sciatic denervation causes lymph node expansion. Loss of sympathetic, adrenergic tone induces the expression of IFN-gamma in LN CD8 T cells, which is responsible for LN expansion. Surgery-induced IFN-gamma expression and expansion can be rescued by beta 2 adrenergic receptor agonists but not sensory nerve agonists. These data demonstrate the mechanisms governing the pro-inflammatory effect of loss of direct adrenergic input on lymph node function.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0022-1007
• Sprache: Englisch