Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to β-subunits of glycoprotein hormones

Fink, Edwin; Hehlein-Fink, Christa und Eulitz, Manfred (September 1990): Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to β-subunits of glycoprotein hormones. In: FEBS Letters, Vol. 270, No. 1-2: pp. 222-224

Abstract

The amino acid sequence of the acrosin-trypsin inhibitor HUSI-II from human seminal plasma is presented which unequivocally identifies HUSI-II as being of Kazal-type. In addition, the HUSI-II sequence shows a striking similarity to the middle part of glycoprotein hormone β-subunits thus revealing a hitherto unknown structural and evolutionary relationship between Kazal-type inhibitors and glycoprotein hormones

• Item Type: Journal article
• Keywords: Kazal-type inhibitor; Glycoprotein hormone β-subunit; Acrosin-trypsin inhibitor (human seminal plasma); Chorionic gonadotropin; Luteinizing hormone
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 0014-5793