Autoantibodies to cortactin and agrin in sera of patients with myasthenia gravis

Doppler, Kathrin; Hemprich, Antonia; Haarmann, Axel; Brecht, Isabel; Franke, Maximilian; Kröger, Stephan; Villmann, Carmen und Sommer, Claudia (2021): Autoantibodies to cortactin and agrin in sera of patients with myasthenia gravis. In: Journal of Neuroimmunology, Bd. 356, 577588

Abstract

Autoantibodies against agrin and cortactin have been described in patients with myasthenia gravis. To further validate and characterize these autoantibodies, sera and/or plasma exchange material of 135 patients with myasthenia gravis were screened for anti-agrin or anti-cortactin autoantibodies. Autoantibodies against cortactin were detected in three patients and two controls and could be confirmed by cell-based assays using cortactintransfected human embryonic kidney cells in both controls and one patient, but were not detectable in followup sera of the three patients. We did not detect any autoantibodies against agrin. The clinical phenotype of anti-cortactin-positive patients varied, arguing against a relevant pathogenic role.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0165-5728
• Sprache: Englisch