Intrinsically disordered proteins at the nano-scale

Ehm, T.; Shinar, H.; Meir, S.; Sekhon, A.; Sethi, V; Morgan, I. L.; Rahamim, G.; Saleh, O. A. und Beck, R. (2021): Intrinsically disordered proteins at the nano-scale. In: Nano Futures, Bd. 5, Nr. 2, 22501

Abstract

The human proteome is enriched in proteins that do not fold into a stable 3D structure. These intrinsically disordered proteins (IDPs) spontaneously fluctuate between a large number of configurations in their native form. Remarkably, the disorder does not lead to dysfunction as with denatured folded proteins. In fact, unlike denatured proteins, recent evidence strongly suggests that multiple biological functions stem from such structural plasticity. Here, focusing on the nanometer length-scale, we review the latest advances in IDP research and discuss some of the future directions in this highly promising field.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Physik
• Themengebiete: 500 Naturwissenschaften und Mathematik > 530 Physik
• Sprache: Englisch