Abstract
Background/Aim: Intraarterial Technetium-99m-Macroaggregated Albumin (Tc-99(m)-MAA) administration is an established method to predict particle distribution prior to radioembolization. This study aimed to analyse the impact of intraarterial administration of Tc-99(m)-MAA on changes in liver-specific laboratory parameters and to assess whether such changes are associated with post-radioembolization hepatotoxicity. Patients and Methods: A total of 202 patients treated with radioembolization received prior mapping angiography with Tc-99(m)-MAA administration. All patients underwent clinical and laboratory examinations, including liver-specific parameters at certain times before and after mapping angiographyl Tc-99(m)-MAA administration, as well as before radioembolization and during follow-up. Results: Bilirubin increased temporarily after Tc-99(m)-MAA administration (p<0.001), but was not clinically relevant, and returned close to the initial value before radioembolization. These changes showed no association with subsequent postradioembolic hepatotoxicity or shortened overall survival. Conclusion: Tc-99(m)-MAA administration results in a significant, however, not clinically relevant transient increase in bilirubin levels, which does not provide a predictive value for subsequent radioembolization outcome or postradioembolic hepatotoxicity.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| Fakultät: | Medizin |
| Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
| ISSN: | 0250-7005 |
| Sprache: | Englisch |
| Dokumenten ID: | 97994 |
| Datum der Veröffentlichung auf Open Access LMU: | 05. Jun. 2023 15:27 |
| Letzte Änderungen: | 17. Okt. 2023 14:57 |
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